- 23
- 154 113
Daniel Beard
Приєднався 12 чер 2012
The Virtual Physiological Rat Project aims to simulate the integrated cardiovascular function of the rat, and to build validated computer models that account for genetic variation across rat strains and physiological response to environment (i.e., diet).
Probing the Regulation of Mitochondrial Substrate Transport and Oxidation
In this talk from May 6, 2021, we discuss mitochondrial respiratory control in skeletal versus cardiac muscle, work through some basic calculations relevant to mitochondrial thermodynamics and energetics, and review some recent modeling and simulation results.
Переглядів: 198
Відео
The Descending Limb of the Starling Curve
Переглядів 5654 роки тому
This video reviews the history of the concept of the descending limb of the Frank-Starling Curve, a concept has been debated for 100 years. A review of the experiments from the cardiovascular research literature clarifies that a reduction in cardiac output with increasing preload a "descending limb" indeed does appear under certain pathological situations, potential including acute and chronic ...
How metabolic energy supplies determines myocardial mechanical power output
Переглядів 3184 роки тому
A talk given May 21 2020 for the Michigan Integrative Aspects of Diabetes, Obesity and Metabolism Research Club.
Cardiomyocyte Electrophysiology & Calcium Handling
Переглядів 4,1 тис.5 років тому
This video is about the cellular and molecular basis of cardiac pumping. Topics include the electrophysiological basis of the cardiac action potential (which triggers the heart beat), and how that action potential is coupled to calcium signaling, and how calcium triggers contraction.
Myocardial Perfusion
Переглядів 9 тис.5 років тому
This video describes the basic mechanisms governing coronary blood flow; the relationship between myocardial work and myocardial oxygen consumption; myocardial oxygen demand/delivery matching, metabolic regulation; ventricular-vascular mechanical interactions; and epi- versus endocardial flow patterns. Learning objectives are: (1.) the gross vascular supply and venous drainage of the heart; (2....
Gravity and Cardiovascular Response to Postural Change
Переглядів 32 тис.5 років тому
This video explains the major cardiovascular compensations that occur during a change in posture, moving from a supine to a standing position. The learning goal is to identify the primary disturbances and compensatory responses evoked by acute changes in body position.
Physiology of Blood Pressure Control
Переглядів 8 тис.5 років тому
This video teaches the major mechanisms controlling arterial blood pressure. These are important physiological concepts-also important in disease. Learning objectives are: (1.) know the location of the arterial baroreceptors and their operation; (2.) understand the sympathetic and parasympathetic outputs from the medullary cardiovascular centers change in response to changes in arterial pressur...
Cardiovascular System Response to Left Ventricular Failure
Переглядів 1,6 тис.5 років тому
This video outlines major compensatory responses of cardiovascular system response to the pathological stimulus of decreased cardiac pumping. A major learning objective is to understand why pulmonary pressures tend to increase more dramatically than the systemic venous pressure in left heart failure.
Pressures Flows & Volumes in the Cardiovascular System
Переглядів 8515 років тому
This video lecture illustrates how the vascular system, as whole, interacts with the pumping of the heart, to work toward and understanding of the systems interactions of pressure and flows coming into and out of the heart. Major learning objectives are: (1.) Define and interpret the relationships among blood flow, blood pressure, and vascular resistance; (2.) Describe how arterial and venous c...
The Cardiac Cycle
Переглядів 6 тис.5 років тому
This video goes over the major distinct phases of the cardiac cycle as delineated by valve opening and closure, introduces the ventricular pressure-volume loop and its interpretation, and delineates approximate values for normal pressures and flows in the human circulatory system. Learning objectives are to: (1.) Describe the pressure and volume changes in the atria, the ventricles, and the aor...
Cardiovascular Physiology: Physical Concepts and Terminology
Переглядів 1,8 тис.5 років тому
This video introduces four physical concepts that are important in cardiovascular physiology and cardiology: Pressure, Flow, Work, and Power.
Definitions, Notation, and Basic Concepts in Statistics and Probability
Переглядів 8785 років тому
This video introduces some terminology, definitions, and basic formulae for probability and statistics. Simple numerical experiments are used to demonstrate how to compute means and variances from discrete and continuous distributions, and to compare to theoretical expectations. This video is intended to be part of a series of short videos illustrating key concepts from probability and statisti...
Thinking about Standard Error
Переглядів 1475 років тому
Presented by Dan Beard, inspired by Curran-Everett (Adv. Physiol. Educ.) 32:203-208, 2008, this video introduces the concept of standard error of the estimate of the mean of a population. Simple numerical experiments are used to demonstrate how and why the standard error is estimated from the estimated population standard deviation divided by the square root of the number of samples. This video...
OpenCOR and the Physiome Model Repository PMR for simulation of CellML models
Переглядів 7039 років тому
This tutorial shows you how to install and run the OpenCOR software [1], to author and edit CellML models [2] and to use the Physiome Model Repository (PMR) [3]. 1. Garny A and Hunter PJ. OpenCOR: OpenCOR: a modular and interoperable approach to computational biology. Frontiers in Physiology 6, 26 (2015). 2. Cuellar AA, Lloyd CM, Nielsen PF, Halstead MDB, Bullivant DP, Nickerson DP and Hunter P...
Annotating and Managing Computational Biology with SemGen: Part 1
Переглядів 1549 років тому
SemGen is a software tool designed to associate semantic information about the physiology contained within a computational model to the model codewords. Computational models annotated with these unambigous and machine readable terms can be merged, extracted, visualized and linked to external data in a mulltitude of ways. In this tutorial we will show you how to download and install SemGen, uplo...
How Superoxide and Hydrogen Peroxide are Generated by NADH:ubiquinone oxidoreductase (Complex I)
Переглядів 2,5 тис.9 років тому
How Superoxide and Hydrogen Peroxide are Generated by NADH:ubiquinone oxidoreductase (Complex I)
Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake
Переглядів 58110 років тому
Ca2 dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2 uptake
A computational analysis of the long-term regulation of arterial pressure
Переглядів 75910 років тому
A computational analysis of the long-term regulation of arterial pressure
Introduction to Simulation of Biological Systems
Переглядів 12 тис.12 років тому
Introduction to Simulation of Biological Systems
great video, thank you!
as oer heart rate if someone in supine has 66-70 heart rate im sitting 72-78 and in standing 85-90 is consider normal?i mean supine to standing 15-20 heart beat difference are normal?Also if we stand for 1 hour heart rate will up more or will go down?
Interesting
wth
What condition (ie combo of carbs/fats) causes large amounts of superoxides and especially hydroxyls to be generated in people with Metabolic Syndrome?
You can be the best if improve to explain what is going on in your mind best of luck
Dear Mr. Daniel. In the most of modern textbooks dedicated to cardiovascular physiology one can find that Frank-Starling relationship is defined as a stroke volume (SV) plotted against preload, so that SV is monotonic and increasing function of preload; is also stated that preload can be presented as left ventricular end-diastolic volume or pressure (!) implying that reader can use them interchangebly. The latter seems quite strange, because first of all we talk about volumes in Frank-Starling relationship only, aren't we? And for the second, such interchangeability (i.e. LVEDP and LVEDV) neglects the concept of compliance. Compliance represensts the first derivative dLVP/dLVV (left ventricular pressure and volume respectively) and is not constant for full possible range of left ventricular pressure values, suggesting that is also the function of pressure. For example in article of Noble (doi.org/10.1042/cs0540001), the idea of SV as function of LVEDV is criticised, because: "... stroke volume/end-diastolic volume curve describes a different property of the heart (i.e. the constancy of end-systolic volume for a given end ejection pressure) from the length-tension curve of the muscle". The same author concludes "... the relationship between stroke volume and end-diastolic volume gives no information about the pressure-volume or length-tension curves" . So my question is which variable should we use, when describing the preload? Thank you!
When you are explaining what would happen in pipes, shouldn’t the pressure in the arteries that is in level with the heart (like a. Brachialis) change when lying down vs standing. Because when you lie down you’re heart will loose the 0.5 meters to the head (roughly 40 mmHg). I agree with you that this is not the case in humans because the baroreceptor reflex will kick in (and the receptors are very close to the heart and have the same height)
Thank you. I have a very bad professor for a grad course, and I could NOT understand how to do systems of ODEs with multiple variables. I was missing just one piece of such simple information. If my own professor had just done a tutorial like this for us, I would be enjoying this course so much more. THANK YOU for saving me in my class!!!
Thank you for this video but I have a question: what is the value of pression in the right atrium and in the left atrium?
thank you, but what is k1,k2 and Km, please
K1 is first forward reaction k2 is 2nd forward reaction and km is 1st backward reaction
Very nice and interesting video ! Thank you !
great work. we enjoyed....
I’ve been struggling for 5 months,and you made it simple in 15 minutes god bless you
Tech itch - feel the pressure drop, feel the pressure drop ..
So increasing gravity kill more people than nuclear bomb no wonder north Korea move people into underground or mountain and increase gravity
Interesting
I will verify the potency of the , Notovα Shocking Plan (look it up on Go ogle) that works with blood pressure level. Several other products I`ve tried only reduced the blood pressure for the moment. There is no other treatment on the market that accomplish what it reveals. After a couple of weeks, my blood pressure level has kept the 145/90 line. With Perfect Pressure its now working at 120/70.
Some resources on quantitative analysis of oxidative phosphorylation can be found here: beards-lab.github.io/QAMAS_book/Abstract.html
super helpful, very informative!
A close friend closed to me have used also this , Notovα Shocking Plan blood pressure level alternative I uncovered on Go ogle. His hypertension was stroke level 158/120. A result of this method is so visible instantly specially if you eat the ideal foodstuff. It has gradually dropped and Fourteen days later with healthier eating his blood pressure is 128/84..
Thank you so much! I have mock exams tomorrow for my second year medical course, and I am definitely weakest in physiology. Not sure watching this today will save my grade tomorrow, but I'm going to come back and study it in more detail after the mock because it was really helpful :)
Dear Tabitha--good luck, and hope the video helps. Don't be shy about making requests. No promises, because it takes time to pull these together. But glad they are of some value.
I have experienced high blood pressure & consuming prescriptions from the time that I was 26 years old. Right here is the very first high blood pressure solution that has ever really worked to reduce my pressure the natural way. The medicinal drugs prescribed to me to take weren`t of used anymore after having a four week period of making use of this guideline. I researched about this tip by Google. This guide is Jason Cυnobroke With thanks
Nice video, Dan!
Thanks!
Several times in the text I mistakenly refer to "Sarnoff and Braunwald", where the correct reference should have been to "Sarnoff and Berglund", as referenced in the slides.
Why when we wound in our foot we feel heavy in wounds like presure on wound area, but when we make horizontal position like rest in bed, the presure on wound like disappear
Sir, How to compute the k values if the concentration time curve is given.
Could u explain the effects of twice the amount of Earths gravity on larger planets on the muscles, skeleton, skin and organs?
our body design to work with gravity.. that why we can mange to walk without need someone to teach you... long bed rest do effect me hard..
@@campkira I'm on about twice Earths gravity though.
Winner of a video, I been tryin to find out about "how to get high blood pressure back to normal" for a while now, and I think this has helped. Ever heard of - Tenaniel Wonderful Eventuality - (do a search on google ) ? Ive heard some pretty good things about it and my neighbour got great success with it.
Never heard of it. The first and most important thing to know about high blood pressure is to know if you have it. It is typically a silent disease. See your doctor to find out and to find out what to do about it.
and for a headstand www.ncbi.nlm.nih.gov/pubmed/31219304?fbclid=IwAR0-vCJ_1HcIVb_kB0zQIykP2aNb1oyNy61Q-9ZNY5ZQSE_sWKK6HAvcg00
There is a much faster way to do all this in Simulink, I personally suggest you can explore that.
I'm not sure how this can be done faster or better in Simulink. But, sure, there are lots of alternatives to simulating kinetics: Python, Julia, Simbio, Matlab, OpenCor, to name a few.
Helpful!
thank you so much for this valuable tutorial...
Here is the Matlab code for this video: %% % Draw samples from a random distribution (mean=0, var=1) % and plot sample mean as function of number of samples N_samples = 100; N = 1:N_samples; x = randn(1,N_samples); figure(1); clf; plot(N,cumsum(x)./N,'linewidth',1.5); xlabel('N_s, number of samples') ylabel('Estimate of the mean') set(gca,'fontsize',16) %% % Repeat above experiment 100 times (N_runs=100) N_samples = 100; N_runs = 100; N = 1:N_samples; x = randn(N_runs,N_samples); figure(2); clf; plot(N,cumsum(x')./N'); hold on; plot(N,1./sqrt(N),'k--',N,-1./sqrt(N),'k--','linewidth',2) xlabel('N_s, number of samples') ylabel('Estimate of the mean') set(gca,'fontsize',16) %% % define and plot Em=estimate of the mean for one experiment Em = (cumsum(x')./N')'; figure(3); plot(N,Em(1,:),'linewidth',1.5) xlabel('N_s, number of samples') ylabel('Estimate of the mean') set(gca,'fontsize',16) %% % plot Em^2 for one experiment figure(4); plot(N,Em(1,:).^2,'linewidth',1.5) xlabel('N_s, number of samples') ylabel('Squared estimate of the mean') set(gca,'fontsize',16) %% % plot Em^2 for all 100 runs of the experiment figure(5); plot(N,Em'.^2) xlabel('N_s, number of samples') ylabel('Squared estimates of the mean') set(gca,'fontsize',16) %% % plot to RMS of the Em from the 100 runs of the experiment figure(6); plot(N,sqrt(mean(Em.^2)'),'linewidth',1.5) xlabel('N_s, number of samples') ylabel('Root of mean of squared E_m') set(gca,'fontsize',16)
Thanks for the video. I come back to this every time I have to do kinetic modeling.
H+1(O3)-1 H2O2 H20 6N2 + 3O2 = 6N2O = 6N2 + 2O3 Heat pressure. Ionization p+ e-
Thank you for you explanations, it made more clear view of what steps I should take to build a biological model.
Hello, What about inhibitor kinetics? I + HMGR (E) ----> K2 K-2 ---> EI
Hi Daniel. It is a great video clip. Thank you. But, could you please explain a little bit about the PLUS and MINUS signs in the differential equations? I'm not 100% sure the signs. Gabriel, if you can help, it is appreciated too. Thanks.
Very helpful!
Awesome video!
Awesome video! Super informative.
Hii.. today's is my exam and i really wanted to know as soon as possible the initial values for n, m, h ??? and also, the V(m) value that is membrane potential value ? will it be -70mV or will it change for three of n, m , h? please answer..
Really thanks you
What is the unit of Y axis and why we have to put initial conditions as 1? thank you
Thank you a lot for help in understanding this material.
Hi, We have a big problem in simulation for the kinetic reaction. The problem is in the ode function with the comment : undifinded function with double and arguments. Can you help us please ! Best of regards.
thanks alot sit 😃
This is a rat model you've used, do I understand correctly? So there's probably no provision in it for gravitational hydrostatic column delta P, is there?
Thank you, very helpful videos that made the concept easier for me!